US Food and Drug Administration approves ‘tudorza pressair’ for the treatment of ‘COPD’

The US Food and Drug Administration (FDA), has approved a drug: ‘Tudorza Pressair’ for the treatment of Chronic Obstructive Pulmonary Disease [COPD].

The FDA announced last week that it had approved the aclidinium bromide inhalation powder, for the long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema .

Bronchospasm is where the muscle walls of the airways in the lung (bronchioles) suddenly constrict, causing mild to severe difficulty in breathing.

Tudorza Pressair, distributed by Forest Laboratories subsidiary Forest Pharmaceuticals ofSt. Louis, is a long-acting dry powder that is inhaled twice a day to help the muscles of the large airways stay relaxed and open to improve airflow.

The product is a multiple-dose inhaler, Pressair, that delivers 60 doses of aclidinium bromide powder.

The agent is a type of anticholinergic known as a long-acting M3 muscarinic antagonist.

Howard Solomon, Chairman, Chief Executive Officer, and President of Forest Laboratories said:
“As the first long-acting inhaled anticholinergic agent approved in over 8 years for COPD, Tudorza will be an important treatment option available for the millions of patients living with this serious disease. ”

The company expects to be making the drug available to wholesalers in the fourth quarter of 2012.

COPD is a common, serious, debilitating and progressive lung disease where the airflow to and from the lungs becomes increasingly limited.

COPD is currently the third leading cause of death in the United States.

The World Health Organization (WHO) has described it as a global epidemic, with 64 million worldwide living with the disease.

90% of cases result from smoking.

Symptoms include chest tightness, increasing difficulty breathing, becoming breathless, too much sputum or phlegm, and a chronic cough.

There is currently no cure, and doctors don’t know how to reverse the damage to the airways and lungs.

As the disease progresses the airways in the lungs lose their elasticity, produce excess mucus and become thick and inflamed. This leads to air trapping, where air can’t be exhaled because the tiny air sacs, the alveoli,are over-inflated, and also to pulmonary emphysema (holes in the lung filled with air that reduce the lung surface area).

People with COPD can find their quality of life greatly impaired, as even daily activities such as walking up a short flight of stairs, or carrying shopping or a suitcase, can become very difficult.

Early detection is the key to successful treatment of COPD,so scientists are always looking for ways to spot the symptoms earlier, before people start feeling them.

For instance, recently, an Austrian team reported the possibility of a blood test that could help detect COPD.

In the meantime, people with COPD rely on drugs to alleviate the symptoms, as Curtis Rosebraugh, director of the Office of Drug Evaluation II in the Center for Drug Evaluation and Research at the FDA, explains:
“COPD is a serious disease that gets worse over time.”
“The availability of long-term maintenance drugs for COPD provides additional treatment options for the millions of people who suffer with this debilitating disease,” he added.

The FDA reviewed three randomized, placebo-controlled confirmatory clinical trials (two 12-week trials and one 24-week trial) that tested the safety and efficacy of Tudorza Pressair (400 mcg twice daily).

The trials covered a total of 1,276 patients aged 40 and over, with a clinical diagnosis of COPD, and a smoking history of at least one pack a day for 10 years.

All three trials showed taking Tudorza Pressair significantly improved bronchodilation, compared to placebo.

A Forest company statement reports:
“Mean peak improvements in lung function (FEV1) assessed after the first dose of Tudorza were similar to those observed at week 12 in each study.”

“In two of the three trials, patients treated with Tudorza Pressair also used less daily rescue albuterol compared to placebo treated patients,” they add.

The FDA says although the trials showed no serious side effects from using the drug (the most common ones were headache , inflammation of the nasal passage (nasopharyngitis), and cough), they warn that:
” Tudorza Pressair may cause serious side effects , including paradoxical bronchospasm, new or worsened increased pressure in the eyes (acute narrow-angle glaucoma ), or new or worsened urinary retention”.

Tudorza Pressair should not be used as a rescue therapy to treat sudden breathing problems (acute bronchospasm) and is not recommended for people younger than 18 years.

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Herbert Armstrong : today-in-history

This day in 1892, Herbert W. Armstrong was born.

Herbert founded the Worldwide Church of God in the late 1930s, as well as Ambassador College (later Ambassador University) in 1946, and was an early pioneer of radio and tele-evangelism, originally taking to the airwaves in the 1930s from Eugene, Oregon .

Armstrong preached an eclectic set of theological doctrines and teachings that he claimed came directly from the Bible.

These theological doctrines and teachings have been referred to as Armstrongism .

His teachings included the interpretation of biblical prophecy in light of British Israelism , and required observance of parts of the covenant Law including seventh-day Sabbath , dietary prohibitions, and the covenant law ” Holy Days “.

Armstrong proclaimed that behind world events during his lifespan loomed various Biblical prophecies, and that he was called by God as an ‘ Apostle ‘ and end-time ‘ Elijah ‘ to proclaim the Gospel of God ‘s Kingdom to the World before the return of Jesus Christ .

He also founded the Ambassador International Cultural Foundation , which promoted the arts, humanities, and humanitarian projects.

Through his role with the foundation, Armstrong and his advisers met with heads of governments in various nations, for which he described himself as an”ambassador without portfolio for world peace.

Whether that church exist in Nigeria is what I cannot ascertain
but for sure, the founder was born on July 31, 1892.

The African Union United Nations Operation [UNAMID] in history

The African Union – United Nations Hybrid Operation in Darfur UNAMID is a joint African Union and United Nations peace-keeping mission formally approved by United Nations Security Council Resolution 1769 on July 31, 2007 to bring stability to the war-torn Darfur region of Sudan while peace talks on a final settlement continue.

Its initial 12-month mandate was later extended to July 31, 2010.

Its budget is approximately $106 million per month.

Its force of about 26,000 personnel began to deploy to the region in October 2007.

The 9,000-strong African Union Mission in Sudan (AMIS), which was previously responsible for peacekeeping, completely merged into a new force by December 31, 2007.

The mandate is for a force of up to 19,555 military personnel and 3,772 police, along with a further “19 formed police units comprising up to 140 personnel each.

The peacekeepers were allowed to use force to protect civilians and humanitarian operations.

UNAMID is noted as the first joint UN /AU force and the largest peacek eeping mission.

As of December 2008, it has deployed 15,136 total uniformed personnel, including 12,194 troops, 175 military observers, 2,767 police officers, supported by 786 international civilian personnel, 1,405 local civilianstaff and 266 United Nations Volunteers.

Today-in-History

Automobile manufacturer Henry F was born on July30, 1863, on his family’s farm near Dearborn, Michigan.

When Henry was 15, his father gifted him a pocket watch, which the young boy promptly took apart and reassembled.

Friends and neighbors were impressed and requested that he fix their timepieces too.

Unsatistfied with farm work, Henry left home the next year, at age 16, to take an apprenticeship as a machinist in Detroit.

In the years that followed, he would learn to skillfully operate and service steam engines, and would also study book keeping.

In 1888, Henry married Clara Ala Bryant and briefly returned to farming to support his wife and son, Edsel.

Three years later, he was hired as an engineer for the Edison Illuminating Company.

In 1983, his natural talents earned him a promotion to Chief Engineer.

All the while, Henry developed his plans for a horseless carriage, and in 1896, he constructed his first model, the Ford Quadricycle.

Within the same year, he attended a meeting with Edison executives and found himself presenting his automobile plans to Thomas Edison .

The lighting genius encouraged Henry to build a second and better model

After a few trials building cars and companies, in 1903, Henry established the Ford Motor Company.

HENRY FORD introduced the Model T in October of 1908, and for several years, the company posted 100 percent gains.

However, more than for his profits, Henry became renowned for his revolutionary vision: the manufacture of an inexpensive automobile made by skilled workers who earn steady wages.

In 1914, he sponsored the development of the moving assembly line technique of mass production.

Simultaneously, he introduced the $5-per-day wage ($110 in 2011) as a method of keeping the best workers loyal to his company.

Simple to drive and cheap to repair, half of all cars in America in 1918 were Model T’s.

HENRY FORD died of a cerebral hemorrhage at age 83, near his Dearborn estate, Fair Lane.

YOU CAN ALSO MAKE IT IRRESPECTIVE OF YOUR BACKGROUND

Today-in-History

This day, precisely on July 30, 1972;

Nigeria lost a soccer star by the name OLAWALE

In his days:
He was both a Nigerian football player and coach.

He played at both Professional and International levels as a striker before becoming Africa’s first qualified Professional football coach.

During his time in Nigeria, Olawale won the challenge cup a total of seven times

A stadium in Lagos was named in his honour after death

A foundation was also founded after his death to assist the families of Nigerian ex-international footballers

Olawale left behind eight children

‘ground dey chop person’
“ilẹ n jẹ ‘ẹyan”

sleep on>>>
OLAWALE TESILIMI BALOGUN